|
KMID : 0191120000150060682
|
|
Journal of Korean Medical Science
2000 Volume.15 No. 6 p.682 ~ p.689
|
|
|
A Rat Model for Radiation-Induced Proctitis
|
|
Kang S
Chun M/Jin YM/Cho MS/Oh YT/Ahn BO/Oh TY
|
|
|
Abstract
|
|
|
Radiation proctitis is a frequent acute complication encountered with pelvic irradiation. This study was
aimed at establishing the optimal radiation dose for radiation-induced proctitis in rats. Female Wistar
rats were used. The rectal specimens were examined morphologically at 5th and 10th day following 10-30 Gy
irradiation in single fraction. With increasing dose, mucosal damage became worse, and there was a prominent
reaction after ≥15 Gy. We selected 17.5 Gy as an optimal dose for radiation proctitis and examined
specimens at day 1-14 and at week 4, 6, 8, and 12 after 17.5 Gy. The rectal mucosa revealed characteristic
histological changes with time. An edema in lamina propria started as early as 1-2 days after irradiation
and progressed into acute inflammation. On day 7 and 8, regeneration was observed with or without ulcer.
Four weeks later, all regeneration processes have been completed with end result of either fibrosis or
normal appearing mucosa. This study showed that the radiation injury of the rectum in rat develops in
dose-dependent manner as it has reported in previous studies and suggested that 17.5 Gy in single fraction
is the optimum dose to evaluate the protective effect of various medications for radiation proctitis in face
of the clinical situation.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|